STATISTICAL INFERENCE FOR INFECTIOUS DISEASES
Identifieur interne : 006630 ( Main/Exploration ); précédent : 006629; suivant : 006631STATISTICAL INFERENCE FOR INFECTIOUS DISEASES
Auteurs : Ira M. Longini [États-Unis] ; James S. Koopman [États-Unis] ; Michael Haber [États-Unis] ; George A. Cotsonis [États-Unis]Source :
- American Journal of Epidemiology [ 0002-9262 ] ; 1988.
Abstract
A statistical model is presented for the analysis of infectious disease data from family studies in the community. The model partitions the sources of infection into those from within the household and those from the community at large. The parameters reflecting these sources of infection are estimated as functions of the risk factors. This new model is used to overcome problems associated with the lack of independence of observations in infectious disease data and negative confounding due to the association of unmeasured exposures and immunity. An example of how this new statistical model is used to provide a clearer and less confounded description of risk factor effects is presented for data from influenza A(H3N2) epidemic seasons in the Tecumseh Respiratory Illness Study. The risk factors examined are age and pre-epidemic season antibody level as measured by the hemagglutination-inhibition test, while the outcome is the infection rate. A standard analysis of the data indicates that the efficacy of protective antibodies is 70% in children and only 47% in adults. However, such an efficacy measurement is negatively confounded by past exposure which is age dependent. By means of the model, the true, unconfounded, efficacy of protective antibodies is shown to be 90% in both adults and children.
Url:
DOI: 10.1093/oxfordjournals.aje.a115038
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002005
- to stream Istex, to step Curation: 002005
- to stream Istex, to step Checkpoint: 002462
- to stream Main, to step Merge: 006B48
- to stream Main, to step Curation: 006630
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>STATISTICAL INFERENCE FOR INFECTIOUS DISEASES</title>
<author><name sortKey="Longini, Ira M" sort="Longini, Ira M" uniqKey="Longini I" first="Ira M." last="Longini">Ira M. Longini</name>
</author>
<author><name sortKey="Koopman, James S" sort="Koopman, James S" uniqKey="Koopman J" first="James S." last="Koopman">James S. Koopman</name>
</author>
<author><name sortKey="Haber, Michael" sort="Haber, Michael" uniqKey="Haber M" first="Michael" last="Haber">Michael Haber</name>
</author>
<author><name sortKey="Cotsonis, George A" sort="Cotsonis, George A" uniqKey="Cotsonis G" first="George A." last="Cotsonis">George A. Cotsonis</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:5391541A5785DA2334C2D25A25C4CC2285D1AF11</idno>
<date when="1988" year="1988">1988</date>
<idno type="doi">10.1093/oxfordjournals.aje.a115038</idno>
<idno type="url">https://api.istex.fr/ark:/67375/HXZ-3XSLCF4W-G/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002005</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002005</idno>
<idno type="wicri:Area/Istex/Curation">002005</idno>
<idno type="wicri:Area/Istex/Checkpoint">002462</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002462</idno>
<idno type="wicri:doubleKey">0002-9262:1988:Longini I:statistical:inference:for</idno>
<idno type="wicri:Area/Main/Merge">006B48</idno>
<idno type="wicri:Area/Main/Curation">006630</idno>
<idno type="wicri:Area/Main/Exploration">006630</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">STATISTICAL INFERENCE FOR INFECTIOUS DISEASES</title>
<author><name sortKey="Longini, Ira M" sort="Longini, Ira M" uniqKey="Longini I" first="Ira M." last="Longini">Ira M. Longini</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
<wicri:cityArea>Division of Biostatistics, Department of Epide miology and Biostatistics, Emory University Atlanta</wicri:cityArea>
</affiliation>
<affiliation></affiliation>
</author>
<author><name sortKey="Koopman, James S" sort="Koopman, James S" uniqKey="Koopman J" first="James S." last="Koopman">James S. Koopman</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, University of Michigan Ann Arbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Haber, Michael" sort="Haber, Michael" uniqKey="Haber M" first="Michael" last="Haber">Michael Haber</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
<wicri:cityArea>Division of Biostatistics, Department of Epide miology and Biostatistics, Emory University Atlanta</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cotsonis, George A" sort="Cotsonis, George A" uniqKey="Cotsonis G" first="George A." last="Cotsonis">George A. Cotsonis</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
<wicri:cityArea>Division of Biostatistics, Department of Epide miology and Biostatistics, Emory University Atlanta</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">American Journal of Epidemiology</title>
<idno type="eISSN">1476-6256</idno>
<idno type="ISSN">0002-9262</idno>
<imprint><publisher>Oxford University Press</publisher>
<date type="published">1988</date>
<biblScope unit="vol">128</biblScope>
<biblScope unit="issue">4</biblScope>
<biblScope unit="page" from="845">845</biblScope>
<biblScope unit="page" to="859">859</biblScope>
</imprint>
<idno type="ISSN">0002-9262</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0002-9262</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">A statistical model is presented for the analysis of infectious disease data from family studies in the community. The model partitions the sources of infection into those from within the household and those from the community at large. The parameters reflecting these sources of infection are estimated as functions of the risk factors. This new model is used to overcome problems associated with the lack of independence of observations in infectious disease data and negative confounding due to the association of unmeasured exposures and immunity. An example of how this new statistical model is used to provide a clearer and less confounded description of risk factor effects is presented for data from influenza A(H3N2) epidemic seasons in the Tecumseh Respiratory Illness Study. The risk factors examined are age and pre-epidemic season antibody level as measured by the hemagglutination-inhibition test, while the outcome is the infection rate. A standard analysis of the data indicates that the efficacy of protective antibodies is 70% in children and only 47% in adults. However, such an efficacy measurement is negatively confounded by past exposure which is age dependent. By means of the model, the true, unconfounded, efficacy of protective antibodies is shown to be 90% in both adults and children.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Géorgie (États-Unis)</li>
<li>Michigan</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Longini, Ira M" sort="Longini, Ira M" uniqKey="Longini I" first="Ira M." last="Longini">Ira M. Longini</name>
</region>
<name sortKey="Cotsonis, George A" sort="Cotsonis, George A" uniqKey="Cotsonis G" first="George A." last="Cotsonis">George A. Cotsonis</name>
<name sortKey="Haber, Michael" sort="Haber, Michael" uniqKey="Haber M" first="Michael" last="Haber">Michael Haber</name>
<name sortKey="Koopman, James S" sort="Koopman, James S" uniqKey="Koopman J" first="James S." last="Koopman">James S. Koopman</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006630 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 006630 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:5391541A5785DA2334C2D25A25C4CC2285D1AF11 |texte= STATISTICAL INFERENCE FOR INFECTIOUS DISEASES }}
This area was generated with Dilib version V0.6.33. |